DKK3 and prostate carcinoma: In the DKK3/DKK3b-deficient, PC3 prostate cancer line, expression of DKK3b arrested cell proliferation of the (Fig 5A) at the G0/G1 phase of the cell cycle (Fig 5B) and led to the loss of DKK3b expressing cells by 24–36 h of induction (Fig 5A).