Since combinations of proteins did not perform any better than PlGF alone, we describe only the prediction performance indices for PlGF in the intervals from 22.1–36 weeks of gestation (see red line segments in Fig 1): at 22.1–28 weeks, the sensitivity of PlGF was 53% (FPR = 20%) for overall late-onset preeclampsia (50% for mild and 59% for severe preeclampsia) (Fig 1B); at 28.1–32 weeks, the sensitivity of PlGF was 36% (FPR = 20%) for overall late-onset preeclampsia (30% for mild and 46% for severe preeclampsia) (Fig 1B). This evidence concerns the gene PGF and Onset.