Prediction performance for late-onset preeclampsia at the 28.1–32 and 32.1–36 week intervals did not exceed the values obtained at the 8–16 and 16.1–22 week intervals, with proteins such as RAN, Calcium/calmodulin-dependent protein kinase type II alpha chain (CAMK2A), PlGF, tissue factor (TF), and Cathepsin B being among the most frequently (14 to 44 times out of 100) included as predictors in the optimal LDA prediction models for late-onset preeclampsia (Table 3). The gene discussed is CTSB; the disease is preeclampsia.