Unlike the detection of patients at risk for early-onset preeclampsia, in which maternal background characteristics, PlGF concentration, and maternal blood pressure at the time of sample collection can identify the majority of patients at risk for the development of this syndrome [82,114,118,119], our study indicates that optimal prediction of late-onset preeclampsia may involve two diagnostic steps: the first assessment during early gestation (8–22.1 weeks), using MMP-7, and the second one later during the third trimester (28.1–32 weeks). This evidence concerns the gene MMP7 and preeclampsia.