A previous study reported that MMP-2 is elevated in maternal urine as early as 12–16 weeks of gestation, and an elevated concentration of MMP-2 at 12 weeks predicted the development of preeclampsia with a sensitivity of 100% and a specificity 62.5%; at 16 weeks of gestation, an elevated MMP-2 in maternal urine predicted the development of preeclampsia with a sensitivity of 87.5% and a specificity of 74.1% [168]. The gene discussed is MMP2; the disease is preeclampsia.