Indeed, the SUMMIT Consortium (surrogate markers for micro- and macrovascular hard endpoint for innovative diabetes tools) reported that circulating MMP-7 concentrations were higher in patients with Type 2 diabetes mellitus, correlated with patients’ age, and were independently associated with the prevalence of cardiovascular disease and the burden of atherosclerosis as well as arterial stiffness and plaque inflammation. The gene discussed is MMP7; the disease is diabetes mellitus.