PlGF, PTP-1B (Tyrosine-protein phosphatase non-receptor type 1), and FCN2 (Ficolin-2) were the most frequently selected to predict severe preeclampsia (10-24/100 times) while RAN, TF, FER, and Cathepsin B were the most frequently selected in the best combinations of predictors of mild late-onset preeclampsia (Table 3). This evidence concerns the gene CTSB and preeclampsia.