Patients with FZD6high mesenchymal glioblastomas have a higher risk of recurrence and worse prognosis compared with other glioblastoma molecular and cellular subtypes.61, 62 Ectopic expression of FZD6 in proneural glioblastoma cells induced the expression of stem cell markers and resulted in increased cell proliferation and sphere formation in vitro and in vivo. This evidence concerns the gene FZD6 and glioblastoma.