RHO and cancer: Rho signalling is essential to promote cancer metastasis by regulating cell migration, extravasation and angiogenesis.45, 46, 47 Rho also plays a pivotal role in the PCP pathway: non-canonical wnt signalling controls the convergent extension movements through the activation of Rho and other GTPases during morphogenesis.48 During amphibian gastrulation, PCP activated downstream of Fzd7, Rho and wnt11 is implicated in fibronectin matrix assembly, which in turn is fundamental for the correct migration and polarization of embryonic cells during morphogenesis.