FZD6 and cancer: Ablation of FZD6 strongly inhibited the repopulation of the hematopoietic compartment in the bone marrow after irradiation and transplant of donor cells in mice.60 It is intriguing to speculate that deregulation of Fzd6 signalling in cancer stem cells might promote uncontrolled self-renewal, homing and survival of metastatic cells in secondary organs.