Conversely, ablation of FZD6 expression decreased proliferation of mesenchymal glioblastoma cells.62 Fzd6 controls glioblastoma cell survival and proliferation through activation of the wnt/calcium pathway, Nf-kB and Stat3, which are known to promote a mesenchymal, stem-like state and aggressive behaviour of glioblastoma cells.62, 63, 64. This evidence concerns the gene STAT3 and glioblastoma.