ZNF687 mutations have been observed in severe Paget disease of bone associated with tumor tissue of giant cell tumor (GCT),21 and ZNF687 is translocated with RUNX1 (runt-related transcription factor 1) in acute myeloid leukemia (AML),22 which suggests that ZNF687 might be a potent oncogene. This evidence concerns the gene RUNX1 and bone Paget disease.