CSCs are involved in regulating HCC recurrence.5, 6, 7 Interestingly, GSEA revealed that ZNF687 gene expression significantly correlated with the gene signatures in liver CSCs, liver cancer with EPCAM (epithelial cell adhesion molecule), hematopoietic stem cells, and lymphoid stem cells (Figure 3a; Supplementary Figure 2), suggesting that ZNF687 may have a regulatory role in HCC stemness. This evidence concerns the gene EPCAM and liver cancer.