ZNF687 and hepatocellular carcinoma: CSCs are capable of self-renewal and have multi-lineage differentiation potential, which results in metastasis, chemotherapy resistance, and recurrence in HCC.7, 8, 9, 10 Consistent with TCGA data set GSEA findings that ZNF687 expression was significantly correlated with gene signatures related to HCC metastasis (Supplementary Figures 3A,B), ZNF687 overexpression significantly increased HCC cell invasive capability, but ZNF687 downregulation decreased it (Figure 5a).