ZNF687 and hepatocellular carcinoma: Consistently, we also found that ZNF687 overexpression enhanced HCC metastasis and chemoresistance, whereas ZNF687 downregulation reduced it, and TCGA data set GSEA showed that high ZNF687 expression correlated with the metastasis and chemoresistance signatures, further evidence that ZNF687 has crucial roles in HCC development and progression.