Importantly, HTT, whose expression is abrogated by the pQ expansion in Huntington’s disease, was recently found to facilitate selective autophagy by acting as a scaffold between autophagy adaptor p62/SQSTM1 and core autophagy molecules such as Atg1/ULK1 and Atg8/LC3 proteins [90,91]. The gene discussed is HTT; the disease is Huntington disease.