MRAS and coronary artery disorder: The genetic variants rs17465637 in MIA3, rs9818870 in MRAS, and rs17228212 in SMAD3 have been associated with coronary artery disease in GWA studies (P<5×10−8), although explaining only a small proportion of the coronary artery disease risk (Samani et al., 2007; Erdmann et al., 2009).