In vivo, although both groups of NFATc2 knockdown mice showed higher folds of tumor shrinkage (3.57 fold, 4.73 fold, respectively) after 2 weeks of gefitinib treatment compared to scramble control (3.38 fold) (Figure 4J), the added effects of NFATc2 inhibition were very modest and the effects on the growth curve was not clear-cut (Figure 4—figure supplement 3A). The gene discussed is NFATC2; the disease is neoplasm.