In our study, we have shown that let-7 suppresses the expression of Myc on the mRNA level, and consequently modulates the function of Myc in CD8 T cells, based on our assessment of established Myc targets, supporting the previous observation of Myc as a non-canonical target of let-7 miRNAs in cancer cells (Kim et al., 2009; Sampson et al., 2007). The gene discussed is MYC; the disease is cancer.