Enhancing actomyosin contractility through PPP1R12A or PPP1CB depletion led to nuclear rupture in HeLa, MDA-MB-231, A549, SiHa and HT1080 cancer cells but had little effect on nuclear integrity in telomerase-immortalized hTERT RPE-1 cells and BJ-5ta primary fibroblasts (Supplementary Fig. 12). The gene discussed is PPP1R12A; the disease is cancer.