SIAH1 and breast cancer: For instance, one study suggested miR-944 functioned as a novel oncogenic miRNA and regulated the chemoresistance in breast cancer (He et al., 2016), meanwhile another study reported that the miR-944 expression was severely repressed in breast cancer cells and clinical specimens, and suppressed the cell migration by targeting SIAH1 (Flores-Pérez et al., 2016).