LAMC1, laminin subunit gamma 1, an extracellular matrix structural glycoprotein, is inherently associated with granulosa cell function increasing during follicular development [39], with gene variants linked to premature ovarian failure [40], a disease that is also associated with errors in FOXL2, and the gene also mutated in adult-GCT. This evidence concerns the gene FOXL2 and primary ovarian failure.