These six miRNAs were predicted to have converging regulation of mRNAs involved in ECM-receptor interaction, focal adhesion and the PI3K/Akt signalling pathways, with four miRNAs specifically targeting apoptosis regulator BCL2. High BCL2 expression in GCTs has been shown to correlate with a low proliferation rate as measured by ki-67 and mitotic index and with tumours smaller <10 cm, therefore with low-malignancy GCTs [48]. This evidence concerns the gene BCL2 and neoplasm.