IGHE and allergic asthma: After all, previous studies on murine models of allergic asthma, being a typical Th2-driven and IgE-mediated disease, showed a role of basophils as a starting component of the adaptive immune response: here, basophil depletion resulted in the impaired development of IL-4-producing Th2 lymphocytes and, as a consequence, in the reduction of total and specific IgE production (3).