Activation of p38 could promote metastasis and suppression of the p38 signaling pathway could inhibit cell migration and reduce the invasion of different tumor cells like gastric cancer cells, chondrosarcoma cells and colorectal cancer cells (Huang, Q. et al., 2014; Ren et al., 2014; Tsai et al., 2015; Yan et al., 2015). The gene discussed is MAPK14; the disease is gastric cancer.