AKT1 and Insulin resistance: Recent studies also indicate that baicalin improves glucose tolerance and insulin resistance, enhances insulin sensitivity, and attenuates lipid deposition, the mechanisms of which are related to the activation of Akt/GSK-3β, Akt/Glut4, and PGC1α/Glut4 pathway as well as enhanced PPAR-γ and p-Akt expression (Xi et al., 2016; Fang et al., 2017).