We previously reported in the rat EPM that the anxiogenic-like effects of the 5-HT2 receptor agonist TFMPP administered systemically were prevented by intra-amygdala infusions of the mixed 5-HT2A/2C-receptor antagonist ritanserin, which does not affect basal levels of anxiety in this animal model (de Mello Cruz et al., 2005). The gene discussed is HTR2A; the disease is Anxiety.