PODXL and Parkinson disease: In an Indian family with three affected siblings from the state ofUttar Pradesh, Sudhaman et al. recently identified a homozygous frameshiftPODXL c.89_90insGTCGCCCC that results incomplete loss of PODXL protein [80].Patients developed levodopa-responsive Parkinsonism at 13–17 years of age,developed dyskinesia and off-dystonia, and showed no obvious additional signs.Five additional unaffected siblings as well as the unaffected, consanguineousparents were either heterozygous or did not carry the mutation, which was shown toinfluence neuronal branching.