The present evidence appears most robust for acausative role of CHCHD2 mutations in PD becauseof the description of more than one family with co-segregation of clinical phenotypeand genotype, but less robust for DNAJC13 andTMEM230, because these mutations were found inonly one, albeit large, pedigree, and least robust for RIC3 that has only been reported from one less extensive family. Here, RIC3 is linked to Parkinson disease.