Regardless of the mechanistic details, specific inhibition of BRD3 may be of therapeutic benefit in the case of acquired/inherited muscle-wasting disorders (analogous to the promotion of muscle growth in the case of Myostatin pathway blockade)49, or alternatively to promote myogenic differentiation at the expense of proliferation in the case of rhabdomyosarcoma. The gene discussed is BRD3; the disease is rhabdomyosarcoma.