For three other genes, Tb927.2.2430 (Other/CK2A2), Tb927.7.960 (CMGC/SRPK1) and Tb927.10.14300 (STE11/MRK1), the loss of fitness after in vivo RNAi was even more pronounced, since a decrease in parasitemia or clearance was seen before 96 h (Fig. S3B). This evidence concerns the gene SRPK1 and parasitic infectious disease.