Compared with the uremia group, the protein and mRNA expressions of VEGF increased in the peritoneal tissues of rats in the PD2, Vector-2, PD4, and Vector-4 groups (all P<0.05), while significantly decreased in the VEGF shRNA-2, PD2 + Endostar, VEGF shRNA-4, and PD4 + Endostar groups (all P<0.05). This evidence concerns the gene VEGFA and uremia.