Compared with the uremia group, the number of new blood capillaries distinctly increased in the PD2, Vector-2, PD4, and Vector-4 groups (all P<0.05), while the VEGF shRNA-2 and PD2 + Endostar groups showed a significant reduction in the number of new blood capillaries (both P<0.05). The gene discussed is PAF1; the disease is uremia.