However, under different experimental conditions, without supplement of serum, BMP-2 increases the resistance of MCF-7 breast cancer cells to hypoxia-induced apoptosis, via the activation of both the MAPK pathway and ID-1, and suppression of Caspase-3 (Clement et al. 2000, Raida et al. 2005a). Here, BMP2 is linked to breast cancer.