This effect is also seen with BMP 6, which restores E-cadherin-mediated cell-to-cell adhesion and prevents breast cancer metastasis through the downregulation of miR-21 and δEF1 (ZEB1, whose expression associates with invasive breast cancer phenotype) (Yang et al. 2007, Du et al. 2009, de Boeck et al. 2016). This evidence concerns the gene CDH1 and breast carcinoma.