Upregulation of Noggin and Follistatin by ZEB1 in breast cancer cells induced differentiation of osteoclasts in vitro, suggesting an osteolytic influence in the bone microenvironment (Mock et al. 2015), however the role BMP antagonists play in coordinating the osteoblastic and osteolytic activities in bone metastatic lesions are far from being clear. Here, NOG is linked to breast carcinoma.