The role of excessive GH-IGF-1 hypersecretion on erythropoiesis in acromegaly is a recognized but relatively neglected subject (Grellier et al. 1996, Teramoto & Ouchi 1997, Zoppoli et al. 2011); however, in pediatric and adult GH deficiency, it is well established that GH replacement can lead to increased red blood cell measure and correction of anemia (Christ et al. 1997, Valerio et al. 1997, Bergamaschi et al. 2006, Esposito et al. 2016). This evidence concerns the gene IGF1 and anemia (phenotype).