A total of 468 cases underwent 777 genetic tests related to acromegaly; 73 patients had known genetic/inherited or syndromic features, 28 had an AIP gene mutation, 13 were from other AIP-negative familial isolated pituitary adenomas (FIPA) kindreds, 11 had McCune Albright syndrome, seven had multiple endocrine neoplasia type 1 (MEN1) and two had Carney complex. The gene discussed is AIP; the disease is acromegaly.