Moreover, Blimp-1 directly represses Pd1 transcription by regulating expression of nuclear factor of activated T cells (NFAT)c1, altering local chromatin structure and evicting NFATc1 from its binding sites on the Pd1 gene during the early stages of effector CD8+ T cell differentiation after acute virus infection [105]. This evidence concerns the gene PRDM1 and viral infectious disease.