However, APOL1 appears to be most trypanolytic against Trypanasoma brucei rhodesiense, which occurs primarily in the eastern continent [6, 10, 13], and although the prevalence of APOL1 risk alleles appears to be lower in many east African populations, the relationship between these alleles and CKD has not been widely explored [6, 12]. The gene discussed is APOL1; the disease is chronic kidney disease.