Pregnant women who developed GDM had significantly (p<0.01) raisedfasting blood glucose, (p<0.014), BMI (P = 0.022),leptin, progesterone, estradiol (p<0.0001) than the pregnant women with low risk of diabetes (Table 3)but significantly low(p<0.0001) human placenta lactogen levels. This evidence concerns the gene LEP and gestational diabetes.