Another study has reported a role of galectin-3 in promoting spheroid formation of lung cancer cells through activation of EGFR.38 Although that study did not identify the relevant galectin-3 binding ligand, their discovery of the requirement of the galectin-3 carbohydrate recognition domain is broadly in keeping with the effect of galectin-3–MUC1 interaction on EGFR activation, as shown here. This evidence concerns the gene LGALS3 and lung carcinoma.