LGALS3 and metastatic malignant neoplasm: Moreover, the concentration of exogenous galectin-3 used in this study is close to the pathological level of circulating galectin-3 in metastatic cancer patients.24 The impact of exogenous galectin-3 on EGFR activation via interaction with MUC1 reported in this study is therefore likely to be particularly relevant to circulating tumour cells during metastasis.