LGALS3 and cancer: Overexpression of galectin-3 commonly occurs in cancers such as colorectal, breast, lung, prostate, pancreatic, head and neck cancer and melanoma.23 This overexpression can be marked (up to 30-fold) particularly in those with metastasis24 and is increasingly shown to influence cancer cell-cell and cancer-microenvironment communication by interaction with various galactose-terminated glycans on the cell surface as well as in the extracellular matrix.25