TSC2 and Alzheimer disease: According to Shang et al., it was proposed that phosphorylation of threonine at position 1462 of Tsc2, a target of Akt1, is increased in AD [37], and supported by the finding that Tuberin (TSC2) was hyperphosphorylated at Thr1462 in postmortem frontal cortex tissue of both AD and PD/DLB patients [38].