Ionizing radiation achieves this in multiple ways: release of pro-inflammatory cytokines (such as interferon-γ), increased production and variety of tumor-associated antigens, and expression of molecules on tumor cells that make them susceptible to T-cell-mediated killing (calreticulin, MHC class 1, CD95, and NKGD2) (15, 43). The gene discussed is CALR; the disease is neoplasm.