The mechanisms of antibody-based tumor cell killing are as follows: (1) antibody can directly bind to the cell surface receptor, deliver drug or toxin to target tumor cells, induce cell apoptosis, and reduce proliferation; (2) antibody can kill tumor cells by immune-mediated killing mechanisms such as activating complement, antibody-dependent cellular cytotoxicity, and regulating T cell function; (3) antibody can regulate tumor angiogenesis by vasculature receptor antagonism or ligand trapping (78, 79). The gene discussed is CD177; the disease is neoplasm.