While these alternative treatments, such as monoclonal antibodies daclizumab, alemtuzumab, and ocrelizumab may also elicit ADA responses not yet sufficiently been studied with regards to loss of efficacy or safety, a proportion of patients with mild to moderate forms of MS will continue to be treated with IFN-β despite the occurrence of ADA and the loss of bioactivity of the drug. The gene discussed is IFNB1; the disease is myeloid sarcoma.