Indeed, SRE SNPs were among the most significant associations not only in the autoimmune disorders (such as previously shown using eQTL mapping in lymphoblastoid cells and whole blood)46, 47 but also, intriguingly (because our definition of SRE is, initially, non-tissue-dependent), in type 2 diabetes (a disease which implicates multiple tissues, including beta cells and insulin-responsive peripheral tissues such as adipose, muscle and liver). The gene discussed is INS; the disease is type 2 diabetes mellitus.