Although we observed increased expression and function (measured as the tissue prostaglandin [PG] E2 content) of Cox-2 in ApcMin/+ mouse tumour tissue compared with adjacent non-neoplastic colonic mucosa (Fig. 2I,J), as has previously been reported26, we did not detect increased levels of Cox-2 mRNA or PGE2 in whole transgenic tumour samples compared with non-transgenic ApcMin/+ mouse tumours (Fig. 2I,J). The gene discussed is PTGS2; the disease is neoplasm.