Method A is better than Method B in predicting the occurrence of brain metastasis since the serum LDH levels evaluated by Method A shows relevance with brain metastasis but not Method B. The combination of tumor LDH-A expression and serum LDH levels evaluated by Method B shows a better prediction for BMFS in the LDH-A positive group, which suggest that Method B should be used when tumor LDH-A expression is positive. Here, LDHA is linked to neoplasm.