Furthermore, SP1 participates in numerous cellular processes, especially, immunoreaction12, for example, Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation, Cell-specific transcription of leukotriene C(4) synthase involves a Kruppel-like transcription factor and Sp115. The gene discussed is LTC4S; the disease is inflammation.