RELA is the most common member of nuclear transcription factor NF-kB family in mammalian cells, the target genes regulated by it include immune related receptors, cytokines, inflammatory cytokines, adhesion molecules and acute phase proteins, so it plays an important role in regulation of immune cell activation, T, B lymphocyte development and a variety of autoimmune disease occurrence16. This evidence concerns the gene NFKB1 and autoimmune disease.