Taken module 2 as an example, the gene sets in module 2 were the functional gene sets relevant with protein kinases and signaling pathways, and the side effects within module 2 were heart related illnesses such as arrhythmia, supraventricular tachycardia (SVT), sinus tachycardia, ventricular extrasystoles, shock and hypokalemia. The gene discussed is WEE1; the disease is cardiac arrhythmia.