The second finding was a missense variant REV3L (rs3204953, encoding p. Val3064Ile) belonging to the 0.1% most deleterious variants within the human genome (CADD = 32.0)25 which was associated with a ratio between tyrosine and methionine and showed significant association with type 2 diabetes in databases after correction for multiple testing. This evidence concerns the gene REV3L and type 2 diabetes mellitus.