In summary, we identified a novel metabolite locus (MOGAT2) in single variant analyses and four genes (GFRAL, BIN1, TFRC, OR51Q1) within gene-based tests and could show that two previously known mGWAS loci (FADS1 and REV3L) might be relevant for the risk of type 2 diabetes. This evidence concerns the gene GFRAL and type 2 diabetes mellitus.