Increasing evidence supporting a role of Lp(a) in the pathogenesis of cardiovascular disease, together with the development of several novel therapeutics that significantly reduce plasma levels of both LDL and Lp(a), make it imperative to extend our understanding of the metabolism of Lp(a).19 The current study examined the effects of CETP inhibition on the clearance and production of Lp(a). The gene discussed is CETP; the disease is cardiovascular disorder.