The third study, which used CLIP-Seq and splicing-sensitive microarrays with HeLa human cervical cancer cells, was the first to identify (1) RBM10 as a regulator of alternative splicing of the NOTCH signaling regulator NUMB, in a cancer cell line, and (2) an RBM10 mRNA target binding motif [2]. The gene discussed is NUMB; the disease is cervical cancer.