Null mutations in RBM10 affect development of the brain, face, heart, lungs, kidneys, limbs and central nervous system during early embryogenesis: the most aggressive phenotypic manifestation of null RBM10 mutation is TARP syndrome (comprising Talipes equinovarus, atrial septal defect, Robin sequence and cleft palate), an X-linked recessive disorder that results in early mortality—predominantly as a result of heart conduction defects [9, 10]. The gene discussed is RBM10; the disease is atrial septal defect.