RBM10 and breast cancer: When we applied unsupervised hierarchical clustering analysis to look for patterns in cell line association, however, while the data showed a good separation of the 28 changes into two major clusters—those consistently experiencing preferential exon exclusion associated with RBM10 KD, and those consistently experiencing preferential exon inclusion associated with RBM10 KD, there was no clustering of changes to either ovarian cancers or breast cancers (Fig. 2).