Hierarchical clustering analysis (Fig. 3) revealed that 12.5% (3/24) of the changes occurring in the BJT cells and only one other cancer cell line (in genes KIF9, LOC219854/TMEM218 and RNF135) showed a shift in the BJT cells opposite to that which occurred in the cancer cells; however, in each of the three instances, preferential exon exclusion was seen in the cancer cells, but preferential exon inclusion in the BJT cells. This evidence concerns the gene TMEM218 and cancer.