CD4 and rheumatoid arthritis: In the present study, we aimed to identify biological networks and signature protein coding genes that are associated with achieving sustained drug-free remission (sDFR) after initiating treatment with tocilizumab, methotrexate, or the combination of both, by performing whole transcriptome ribonucleic acid sequencing (RNA-seq) of positive cluster of differentiation 4 (CD4+) and CD14+ cells obtained from DMARD-naive early RA patients.