As shown in Table 3 focusing on the joint effect of smoking and drinking amount, the ORs of the prevalence of NAFLD in subjects who smoked ≥40 pack-year were 1.60 (95% CI:1.16 to 2.20) for non-drinker, 1.73 (1.15 to 2.60) for light drinker < 80 g/week, and 1.85 (1.28 to 2.68) for moderate drinker (80 ~ 210 g/week) with participants who neither smoked nor drank alcohol as reference, after adjusting age, BMI, waist, diabetes, AST/ALT, HDL, LDL, DBP, SBP, TG, TC, UA, physical activity, past history of CHD and hypertension. The gene discussed is GPT; the disease is diabetes mellitus.