Of note, the prevalence of NAFLD in current smokers with more than 40 pack-year was gradually increased with drinking duration (34.14%, 34.44% and 36.80%);however, the risk of NAFLD failed to linearly increase with drinking duration when adjusted for age, BMI, waist, diabetes, AST/ALT, HDL, LDL, DBP, SBP, TG, TC, UA, physical activity, past history of CHD and hypertension. The gene discussed is GPT; the disease is diabetes mellitus.