FLT3 and acute myeloid leukemia: While TAE-684 treatment did not affect Flt3-ITD phosphotyrosine content in Flt3-ITD+ AML cell lines or in TF-1 cells transformed with Flt3-ITD, TAE-684 completely suppressed Flt3-D835Y phosphorylation in TF-1 cells expressing this oncogene.