To determine whether a similar specificity profile was observed in Flt3-ITD+ AML cells, we treated MV4-11 and MOLM-14 cultures with each compound at its calculated IC90 value for Fes from the in vitro kinase assays (or Flt3-ITD in the case of tandutinib). This evidence concerns the gene FLT3 and acute myeloid leukemia.