FTO and metabolic syndrome: One CpG locus out of the 7 loci in the FTO gene indicated differential methylation between the MetS patients and the controls (p = 0.01), with median methylation levels of 2.7% and 2.1% respectively, while another CpG locus in the FTO gene was tending toward significance between the T2D patients and the controls (p = 0.07).