Bacos et al reported a 60% overlap between genes associated with age-related changes in DNA methylation in both leucocytes and pancreatic islets and some of these differentially methylated genes affected insulin secretion[19] and Vanderjagt et al reported that differential DNA methylation in blood was observed in the pre-T2D state[20], suggesting a potential of DNA methylation early in the development of T2D. Here, INS is linked to type 2 diabetes mellitus.