For example, in a genome-wide association study, differentially methylated loci were observed in PBLs from pooled T2D patients versus controls in a genome-wide association study for 3 loci located in the intronic regions of the KCNQ1[44], while none of the CpG loci included for this gene in our study reached statistical significance. Here, KCNQ1 is linked to type 2 diabetes mellitus.