To test whether Caspase-3 played a role in AHCC-induced AML-cell death, we treated all four AML cell lines and primary AML leukopheresis cells with increasing concentrations of AHCC (0, 1, 5 or 10 mg/ml) for 24 hours and measured cleaved Caspase-3. Here, CASP3 is linked to acute myeloid leukemia.