The minor allele of PIK3R1 rs10515074 was associated with reduced risk of hyperglycemia (OR = 0.24, 95%CI = 0.07–0.76, P = 0.016), but increased risk of leucopenia (OR = 5.03, 95%CI = 1.89–13.35, P = 0.001); there was also a trend with lymphopenia (OR = 2.48, 95%CI = 0.92–6.69, P = 0.073), all in multivariable analysis. Here, PIK3R1 is linked to lymphopenia.