For diagnosing bacterial sepsis, the NLCR showed a significantly higher AUC (0.68; 95% CI 0.65–0.71) than PCT (p = 0.019; AUC 0.64; 95% CI 0.61–0.67), CRP (p < 0.001; AUC 0.57; 95% CI 0.54–0.60), and lactate (p < 0.001; AUC 0.57; 95% CI 0.54–0.60; Fig 4C). Here, CRP is linked to bacterial infectious disease with sepsis.