RAMP2 and preeclampsia: Although pregnant Ramp2+/- dams carrying Ramp2-/- embryos do not develop overt preeclampsia, likely due to embryonic lethality of Ramp2-/- embryos, our studies demonstrate that RAMP2 plays a role in spiral artery remodeling distinct from uNK cell recruitment and canonical AM signaling through RAMP2-CLR.