Interestingly, subsequent endothelial restoration of Ramp2 expression is sufficient to partially rescue the Ramp2-/- lethality but not without consequence, since surviving animals develop dilated cardiomyopathy associated with profound dysregulation Gcgr and Pth1r expression [12], indicating that genetic deletion of Ramp2 can impart physiological consequences that extend beyond canonical AM/CLR signaling. This evidence concerns the gene RAMP2 and dilated cardiomyopathy.