After 20 weeks of high salt diet feeding, polyphagia, polydipsia, polyuria, wasting, lipolysis, increased systemic angiotensin II, renal dysfunction & cardiac hypertrophy were observed in rats fed with high salt diet (HSD) and uninephrectomized rats fed with high salt diet (UNX+HSD) compared to Ctrl and UNX groups (Table 2). This evidence concerns the gene AGT and cardiac hypertrophy.