The aCL test is more sensitive, but less specific, than aB2GPI, and patients with APS aCL are closely correlated with aB2GPl.[44] Pierangeli and Harris showed that a screening with aCL (IgG and IgM isotypes) and LA test should capture the majority of APS patients.[45] In this context, the validity of the isolated aCL determination in patients in our environment as screening to identify aPL-negative patients has been demonstrated with the study of 5245 patients (APS-symptomatic and asymptomatic). Here, CD40LG is linked to autoimmune polyendocrinopathy.