We have used AAV2-CHOP shRNA to directly knock down CHOP levels in RGCs and demonstrated that it protects RGC somata and axons in ON crush and glaucoma models.19 We therefore injected AAV2-CHOP shRNA+AAV2-XBP-1s or AAV2-scramble shRNA+AAV2-GFP (control) into WT mice 3 days after MOG immunization. The gene discussed is DDIT3; the disease is glaucoma.