S100A14 and malignant colon neoplasm: Elevated S100A14 promotes the metastasis of tumor cells and induces worse survival in breast cancer,35, 36 ovarian tumors24 and hepatocellular carcinoma.25 However, S100A14 inhibits the invasive potential of oral squamous cell carcinoma31 and urothelial carcinoma,30 and S100A14 expression is inversely associated with multiple lymph node metastases of small intestinal adenocarcinomas37 and distant metastasis of colon cancer.27 S100A14 may have different roles in various kinds of tumors and depend on different potential signaling pathways.