S100A14 was demonstrated to be transcriptionally regulated by JunB and involved in ESCC cell differentiation through upregulating involucrin (IVL) and filaggrin (FLG) expression.28 In our study, S100A14 significantly correlated with the differentiation of gastric mucosa and the statuses of the mature markers PGII32, 33 and E-cadherin34 in GC tissue, and PGII and E-cadherin expression was altered with S100A14 expression in GC cells. Here, IVL is linked to gastric cancer.