Matrix metalloproteinases (MMPs) have a vital role in the tumor invasion process by degrading multiple elements of the extracellular matrix (ECM).20, 46 The 100A14 protein suppressed OSCC cell invasion by downregulating the expression of MMP1 and MMP9,31 and S100A14 either promoted or inhibited cell invasion by regulating MMP2 in a p53-dependent manner.29 Consistent with previous reports,47, 48, 49 our findings imply that S100A14 not only inactivates calpain and stabilized focal adhesion kinase (FAK) but also downregulates the expression of MMPs via decreasing cellular Ca2+ levels. Here, MMP2 is linked to neoplasm.