Another previous study showed that S100A14 expression resulted in G1-phase cell cycle arrest and inhibited cell growth but failed to induce cell apoptosis during the process of promoting the terminal differentiation of ESCC cells.28 However, our cell growth assay and animal model data showed that S100A14 had no effect on GC cell growth in vitro and in vivo (Supplementary Figure 3), which is consistent with the clinical feature, namely, the lack of a significant difference in S100A14 expression between normal tissues and tumor tissues. Here, S100A14 is linked to neoplasm.