As JUN was expressed after ocular hypertensive injury, a floxed allele of Jun and Six3-cre (a neural retina cre) were backcrossed into the DBA/2J mouse to test the importance of JUN signaling in glaucomatous neurodegeneration.43, 44 As recombination efficiency can differ between mouse strains and cell type, the recombination efficiency of Six3-cre was assessed in the DBA/2J genetic background. The gene discussed is SIX3; the disease is hypertensive disorder.