However, because RGC death in glaucoma may differ from experimentally induced axonal injury – in the magnitude of insult, kinetics of RGC cell loss, or extrinsic triggers (glial signaling) versus intrinsic triggers (cytoskeleton disruption) – the role of JUN and JNK must be tested in an ocular hypertensive glaucoma model.30, 31 Furthermore, increasing evidence points to transcriptional events being key mediators of neuronal degeneration. This evidence concerns the gene JUN and glaucoma.