In particular, Sorcin has been shown to be upregulated in doxorubicin-induced MDR K562/A02 leukemia cells over their parent cells, and Sorcin overexpression has been demonstrated to increase drug resistance to doxorubicin, etoposide, homoharringtonine, vincristine, taxol, cisplatin and 5-fluorouracil in several cancer cells.6, 26, 27, 28, 29, 30, 31, 32 Further, many studies have demonstrated Sorcin participation in several processes, such as drug efflux regulation, apoptosis modulation and EMT control, that might contribute to the onset of MDR in human cancers.8, 9. This evidence concerns the gene SRI and leukemia.