In H1299 lung cancer cell line, Sorcin (green fluorescence) localizes to cell membrane, nucleus, ER and cytosol, as already observed in other cellular systems.17 Upon treatment with doxorubicin, Sorcin localization changes with respect to control: after 1-h doxorubicin treatment, cytosolic Sorcin localization increases and nuclear, ER and membrane localization decreases; the ratio of cytosol/(nuclear+ER) Sorcin fluorescence increases by 77% (from 0.278 to 0.491, number of cells=60, P<0.01, Figure 3). This evidence concerns the gene SRI and lung cancer.